WHF Lab

Gao Y^#, Ma Y^#, Yu K^#, Liu Y^#, Gu B, Tang H, Yan W, Yang S, Su J, Wang X, Ma X, Wang X, Wang F, Li Q, Liu M, Wang H*. Efficient and precise programmable DNA knock-in without double-strand breaks, Nature, 2026. Read Online

Liu M^#, Huang K^#, Zhang J^#, Li Q, Wang X, Gu B, Tang H, Du Z, Hu L, Qi S, Ma Y, Yu H, Xie W*, Fang X*, Wang H*. CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci, Nature Biotechnology, 2025. Read Online

Chen Q^#, Wang S^#, Zhang J, Xie M, Lu B, He J, Zhen Z, Li J, Zhu J, Li R, Li P, Wang H, Vakoc C, Roeder R*, Chen M*. JMJD1C forms condensate to facilitate a RUNX1-dependent gene expression program shared by multiple types of AML cells, Protein & Cell, 2025 16-5, 338-364. Read Online

Du Z^#, Hu L^#, Zou Z^#, Liu M^#, Li Z, Lu X, Harris C, Xiang Y, Chen F, Yu G, Xu K, Kong F, Xu Q, Huang B, Liu L, Fan Q, Wang H*, Kalantry S*, Xie W*. Stepwise de novo establishment of inactive X chromosome architecture in early development, Nature Genetics, 2024 56, 2185–2198. Read Online

Yang L^#, Min Y^#, Liu Y^#, Gao B, Liu X, Huang Y, Wang H, Yang L, Liu Z, Chen L*. CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells, Nature Methods, 2024 21, 1646–1657. Read Online

Zhang Z^#, Rong X^#, Xie T, Li Z, Song H, Zhen S, Wang H, Wu J, Jaffrey S, Li X*. Fluorogenic CRISPR for genomic DNA imaging, Nature Communications, 2024 15, 934. Read Online

Li Q, Gao Y, Wang H*. CRISPR-Based Tools for Fighting Rare Diseases, Life, 2022 Nov 24;12(12):1968. Read Online

Lin X^#, Liu Y^#, Liu S^#, Zhu X, Wu L, Zhu Y, Zhao D, Xu X, Chemparathy A, Wang H, Cao Y, Nakamura M, Noordermeer JN, La Russa M, Wong WH, Zhao K, Qi LS*. Nested epistasis enhancer networks for robust genome regulation, Science, 2022 Aug 11;Vol 377, Issue 6610, pp. 1077-1085. Read Online

Wang H^#, Han M^#, Qi LS*, Engineering 3D genome organization, Nature Reviews Genetics, 2021 Feb; PMID: 33558716 Read Online

Wang H, Nakamura M, Abbott TR, Zhao D, Luo K, Yu C, Nguyen CM, Lo A, Daley PT, La Russa M, Liu Y, Qi LS*, CRISPR-mediated live imaging of genome editing and transcription. Science, 2019 Sep; Vol. 365, Issue 6459, pp. 1301-1305. Read Online

Wang H, Xu X, Nguyen CM, Liu Y, Gao Y, Lin X, Daley PT, Kipniss NH, La Russa M, Qi LS*, CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization. Cell, 2018 Oct; 175, 1405-1417 e1414. Read Online

Liu Y^#, Yu C^#, Daley T^#, Wang H, Cao W, Lin X, Still C, Bhate S, Liu H, Zhao D, Wang H, Xie X, Ding S, Wong WH, Wernig M, Qi LS*, CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming. Cell Stem Cell, 2018 Nov; 23(5):758-771.e8. Read Online

Kipniss N^#, Dingal PCD^#, Abbott T, Gao Y, Wang H, Dominguez A, and Labanieh L, Qi LS, Engineering Cell Sensing and Responses Using a GPCR-Coupled CRISPR-Cas System. Nature Communications, 2017 Dec; 2212. Read Online

Wang H, La Russa M, Qi LS, CRISPR-Cas9 in genome editing and beyond. The Annual Review of Biochemistry, 2016 Aug; Vol. 85: 227-264. Read Online

Wang H, Brust-Mascher I and Scholey JM, The microtubule cross-linker Feo controls the midzone stability, motor composition, and elongation of the anaphase B spindle in Drosophila embryos. Molecular Biology of the Cell. 2015 Apr 15; 26(8):1452-62. PMID: 25694445.Selected as the Cover paper. Read Online

Wang H, Brust-Mascher I and Scholey JM, Sliding filaments and mitotic spindle organization, Nature Cell Biology, 2014 Aug; 16(8):737-739. PMID: 25082196 Read Online

Wang H, Brust-Mascher I, Civelekoglu-Scholey G and Scholey JM, Patronin mediates a switch from kinesin-13-dependent poleward flux to anaphase B spindle elongation, Journal of Cell Biology, 2013 Oct; 203(1):35-46. PMCID: PMC3798244. Read Online